Immunohistochemical Analysis of Expression of Cyclin D1 in Different Grades of Oral Squamous Cell Carcinoma

Aims: The present study aimed to evaluate the expression of cyclin D1 in oral squamous cell carcinoma and find association with different histological grades carcinoma.
 Study Design: It is a cross sectional study.
 Place Duration Study: Oral samples were collected histopathology laboratory Ziauddin Hospital, North Nazimabad Karachi. Immunohistochemistry was performed multiple disciplinary research University, duration from January 2021 2022.
 Methodology: included taking biopsy patients. Patients history other cavity tumors, patients any treatment cancer excluded study. on total 150 using anti antibodies.
 Results: A part Expression found be 77.3% cases where as 22.7% did not show D1. statistically significant shown between intensity scoring (p value 0.004). Association labelling index score for showed p (0.003). scores also 0.003).
 Conclusion: shows that oncogenic effects by mutations caused can detected immunohistochemistry form its overexpression. overexpression utilize predicting behavior carcinoma.